Orange City is one of the region's major centers of retail and commerce. Businesses here provide employment for many of the residents in neighboring cities. Spread over 7 square miles, Orange City features over 600,000+ square feet of space in its West Volusia Retail & Town Centers. Headquartered in Orange City is the second largest healthcare facility in the west, Florida Hospital Fish Memorial, with over 139 beds.

The flow of people and goods across Orange City lines represents a similar exchange happening at the government and policy level with the exchange of ideas and efforts as a way to enhance the overall business climate. Orange City's local government welcomes collaborative opportunities with local industry as well as its residents in order to ensure economic prosperity and revitalization.